See recent publications on pubmed here.

Refereed Journal Articles

Zhang X, Simmons CAG, Santerre JP, Alterations of MEK1/2-ERK1/2, IFNγ and Smad2/3 associated signalling pathways during cryopreservation of ASCs affect their differentiation towards VSMC-like cells, Stem Cell Research, 32, 115-125 (2018) https://doi.org/10.1016/j.scr.2018.09.005

Antonyshyn JA, McFadden MJ, Gramolini AO, Hofer SOP, Santerre JP, Limited Endothelial Plasticity of Mesenchymal Stem Cells Revealed by Quantitative Phenotypic Comparisons to Representative Endothelial Cell Controls, Stem Cells Translational Medicine, (2018) https://doi.org/10.1002/sctm.18-0127

Huang B, Cvitkovitch DG, Santerre JP Finer Y, Biodegradation of Resin-Dentin Interfaces is Dependent on the Restorative Material, Mode of Adhesion, Esterase or MMP Inhibition, Dental Materials, 34(9), 1253-1262 (2018). https://doi.org/10.1016/j.dental.2018.05.008

Delaviz Y, Nascimento M,  Laschuk  MW,  Liu T,  Yang M, Santerre JP, Synthesis and characterization of Ciprofloxacin containing di-vinyl oligomers and their polymerization, Dental Materials, 34, 711-725 (2018). https://doi.org/10.1016/j.dental.2018.01.021

Wright, MEE, Wong AT, Levitt D, Yang M, Santerre JP, Influence of ciprofloxacin-based additives on the hydrolysis of nanofiber polyurethane membranes,  Journal of Biomedical Materials Research part A, 106 (5) , 1211-1222 (2018). https://doi.org/10.1002/jbm.a.36318

Gossart A, Battiston, KG, Gand A, Pauthe E,  Santerre JP, Mono vs multilayer fibronectin coatings on polar/hydrophobic/ionic polyurethanes: Altering surface interactions with human monocytes, Acta Biomaterialia, 66, 129-140 (2018). doi.org/10.1016/j.actbio.2017.11.013 

Zhang X, Battiston KG, Simmons CAG, Santerre JP, Differential regulation of extracellular matrix components by altering specific vitamin C derivatives in the culture supplements of mono- and co-culture systems applied towards the engineering of vascular tissues in a degradable polyurethane scaffold, ACS Journal of Biomaterials and Biomedical Engineering DOI:10.1021/acsbiomaterials.7b00389

Iu J, Santerre JP, Kandel RA. Towards engineering distinct multilamellated outer and inner annulus fibrosus tissues. Journal of Orthopaedic Research, 36, 1346–1355 (2018), https://doi.org/10.1002/jor.23793

Delaviz Y, Yang M, Santerre JP, Biodegradation Studies of Novel Fluorinated Di-Vinyl Urethane monomers, Polymer, 9, 365 (2017). https://doi.org/10.3390/polym9080365

Ansari Aysha S, Santerre JP, Uludag H, Biomaterials for Polynucleotide Delivery to Anchorage-Independent Cells,  Journal of Materials Chemistry B, 5, 7238 - 7261, (2017). https://doi.org/10.1039/C7TB01833A

Zhang X, Bendeck M, Simmons CAG, Santerre JP, Deriving vascular smooth muscle cells from mesenchymal stromal cells: Evolving differentiation strategies and current understanding of their mechanisms, Review article, Biomaterials, 145, 9 - 22, (2017). https://doi.org/10.1016/j.biomaterials.2017.08.028

MacAulay M, Tam LE, Santerre JP, Finer Y, In vivo biodegradation of bisGMA and urethane-modified bisGMA based resin composite materials, J Dental Research - Clinical & Translational Research, 2, 397 - 405, (2017). https://doi.org/10.1177%2F2380084417722117

Iu J, Massicotte E, Li S, Hurtig MB, Toyserkani E, Santerre JP, Kandel RA , In Vitro Generated Intervertebral Discs: Towards Engineering Tissue Integration. Tissue Engineering Special Issue - Strategic Directions in Musculoskeletal Tissue Engineering Part A, 23, 1001 - 1010, (2017). https://doi.org/10.1089/ten.tea.2016.0433

Brockman KS, Kizhakkedathu JN, Lai BFL, Santerre JP, Hemocompatibility of Degrading Biomaterials: Degradable Polar Hydrophobic Ionic Polyurethane (D-PHI) vs Poly(lactic-co-glycolic) Acid (PLGA), Biomacromolecules, 18, 2296 - 2305, (2017). http://dx.doi.org/10.1021/acs.biomac.7b00456 

Xioqing Zhang, Battiston KG, Labow RS, Simmons CA, Santerre JP, Generating favorable growth factor and protease release profiles to enable extracellular matrix accumulation within an in vitro tissue engineering environment, Acta Biomaterialia, 54, 81-94 (2017). http://dx.doi.org/10.1016/j.actbio.2017.02.041

Wright, MEE, Yang M, Santerre JP, Electrospun polyurethane nanofiber scaffolds with ciprofloxacin oligomer: Effect on drug release and cell attachment versus free drug, J Cont Release, 250, 107-115, (2017). https://doi.org/10.1016/j.jconrel.2017.02.008

Sadeghinejad L,  Siqueira W,  Santerre JP, Cvitkovitch DG, *Yoav Finer, Triethylene Glycol Up-regulates Virulence-associated Genes and Proteins in Streptococcus mutanss, PLOS ONE, (2016). https://doi.org/10.1371/journal.pone.0165760 

Sadeghinejad L,  Siqueira W,  Merritt J, Santerre JP, Cvitkovitch DG, *Yoav Finer,  Mechanistic, Genomic and Proteomic Study on the Effects of BisGMA-derived Biodegradation Product on Cariogenic Bacteria, Dental Materials, 33 (2), 175-190 (2017). https://doi.org/10.1016/j.dental.2016.11.007

Brockman KS, Kizhakkedathu JN, Santerre JP, Hemocompatibility Studies on a Degradable Polar Hydrophobic Ionic Polyurethane (D-PHI) , Acta Biomaterialia, Accepted Nov 2016, 48, 368-377, (2017). http://dx.doi.org/10.1016/j.actbio.2016.11.005

Hugoni L,  Montaño-Machado V, Pauthe E, Mantovani D, Santerre JP, Fibronectin adsorption on surface-modified polyetherurethanes and their differentiated effect on specific blood elements related to inflammatory and clotting processes. BioInterfaces, 11, 029809 (2016). https://doi.org/10.1116/1.4950887

Parvin Nejad S, Blaser M, Santerre JP, Calderone CA, Simmons CA. Biomechanical conditioning of tissue engineered heart valves: Too much of a good thing?; Advanced Drug Delivery reviews, 96, 161-175 (2016). https://doi.org/10.1016/j.addr.2015.11.003

Xiaoqing Zhang, Kyle G Battiston, Joanne E McBane, Loren A Matheson, Rosalind S Labow, J Paul Santerre, Design of Biodegradable Polyurethanes and the Interactions of the Polymers and their Degradation By-Products within in vitro and in vivo Environments, in #108 Advances in Polyurethane Biomaterials, edited by Gianjun Guan and Stuart L. Cooper,  Elsevier-Woodhead, pages 75-104, February 2016, 691 pages. https://doi.org/10.1016/B978-0-08-100614-6.00003-2

Battiston KG, Labow RS, Simmons CA, Santerre JP, Immunomodulatory polymeric scaffold enhances extracellular matrix production in cell co-cultures under dynamic mechanical stimulation, Acta Biomaterialia, 24, 74-86 (2015). http://dx.doi.org/10.1016/j.actbio.2015.05.038

Battiston KG, Ouyang B, Honarparvar E, Qian J, Labow RS, Simmons CA, Santerre JP, Interaction of a block-co-polymeric biomaterial with immunoglobulin G modulates human monocytes towards a non-inflammatory phenotype, Acta Biomaterialia, 24, 35-43 (2015). https://doi.org/10.1016/j.actbio.2015.06.003

Cheung JWC, Jain D, McCulloch CAG, and Santerre JP, Pro-angiogenic Character of Endothelial Cells and Gingival Fibroblasts Co-cultures in Perfused Degradable Polyurethane (D-PHI) Scaffolds, Tissue Engineering, Part A,  21 (9-10), 1587-1599 (2015). https://doi.org/10.1089/ten.tea.2014.0548

Kandel, R, Santerre J, Massicotte, E, Hurtig M, Tissue Engineering of the Intervertebral Disc, in The Intervertebral Disc, Eds Shapiro IM, Risbud MV, Springer, New York, 2014, ISBN 978-3-7091-1535-0, 437pages (pages 417-433). https://doi.org/10.1007/978-3-7091-1535-0_26

Zhang X, Wright MEE, Jane W.C. Cheung, Battiston KG, Sharifpoor S, Labow RS, and Santerre JP, New Degradable Polyurethanes for Use in Tissue Engineering: Inspired by Mechanisms of Biodegradation and Wound Healing, Journal of Biomaterials and Tissue Engineering, 4, 1–14, (2014). https://doi.org/10.1166/jbt.2014.1271

Cheung JWC, McCulloch CAG, and Santerre JP, Establishing a Gingival Fibroblast Phenotype in a Perfused Degradable Polyurethane Scaffold:  Mediation by TGF-β1, FGF-2, and Activation of β1-integrin and Focal Adhesion Kinase, Biomaterials 35 (38), 10025-10032, (2014). https://doi.org/10.1016/j.biomaterials.2014.09.001

Iu J., Santerre JP, Kandel RA, Inner and outer annulus fribosus cells exhibit differentiated phenotypes and yield changes in extracellular matrix composition in vitro on a polycarbonate urethane scaffold, Tissue Engineering Part A20(23-24):3176-88, (2014). https://doi.org/10.1089/ten.tea.2013.0777

Mathieu E, Battiston KG, McBane JE, Davidson L, Suuronen EJ, Santerre JP, Laow RS, Characterization of a degradable polar hydrophobic ionic polyurethane with circulating angiogenic cells in vitro, Journal of Biomaterials Science-Polymer 25(11):1159-1173, (2014). https://doi.org/10.1080/09205063.2014.923367

Cai K, Delaviz Y, Banh M, Guo Y, Santerre JP, Biodegradation of composite resin with ester linkages: identifying human salivary enzyme activity with a potential role in the esterolytic process, Dental Materials, 30(8):848-860, (2014). https://doi.org/10.1016/j.dental.2014.05.031

Delaviz Y, Cvitkovitch DC, Santerre JP, Infection Resistant Biomaterials in “Biomaterials and medical device associated infections”, ed. Lara Barnes and Ian Cooper , Elsevier, Nov 21, 2014 - Medical - 278 pages. 

Battiston KG, Cheung JWC, Jain D, Santerre JP, Biomaterials in co-culture systems: Towards optimizing tissue integration and cell signaling within scaffolds, Biomaterials, 35, 4465-4476, (2014). http://dx.doi.org/10.1016/j.biomaterials.2014.02.023

Lopez-Donaire M, Santerre JP, Surface Modifying Oligomers Used to Functionalize Polymeric Surfaces: Consideration for Blood Contact Applications, J Applied Polym Sci, 131, (2014). https://doi.org/10.1002/app.40328

Battiston, KG, Ouyang B, Labow RS, Simmons CA, Santerre JP, Monocyte/macrophage cytokine activity regulates vascular smooth muscle cell function within a degradable polyurethane scaffold, Acta Biomaterialia, 10,1146-1155 (2014). https://doi.org/10.1016/j.actbio.2013.12.022

Turner KA, Santerre JP, Kandel RA, Modulation of annulus fibrosus cell alignment and function on oriented nanofibrous polyurethane scaffolds under tension, The Spine Journal, 14(3):424-34 (2014). https://doi.org/10.1016/j.spinee.2013.08.047

Delaviz Y, Finer Y, Santerre JP, Biodegradation of Resin Composites and Adhesives by Oral Bacteria and Saliva. A Rationale for New Material Designs that are Dependent on the Clinical Environment and Treatment Challenges. Dental Materials, 30(1), 16-32 (2014) http://dx.doi.org/10.1016/j.dental.2013.08.201                           

Bourbia M, Ma D, Cvitkovitch DG, Santerre JP, Finer Y, Cariogenic Bacteria Degrades Dental Resin Composite and Adhesives, Jounal of Dental Research, 92(11), 989 – 994 (2013). https://doi.org/10.1177%2F0022034513504436

Nosikova YS, Santerre JP, Grynpas M, Kandel RA, Annulus fibrosus cells can induce mineralization: An in vitro study, The Spine Journal, 13(4), 443-453 (2013). https://doi.org/10.1016/j.spinee.2012.11.050

Cheung JWC, Rose E, Santerre JP, Perfused culture of gingival fibroblasts in a degradable-polar hydrophobic ionic polyurethane (D-PHI) scaffold leads to enhanced proliferation and metabolic activity, Acta Biomaterialia, 9, 6867-6875 (2013). https://doi.org/10.1016/j.actbio.2013.02.010

Nosikova YS, Santerre JP, Grynpas M, Gibson G, Kandel RA, Characterization of the annulus fibrosus-vertebral bone interface: identification of new structural features, Journal of Anatomy, 221(6) 577-589 (2012). https://doi.org/10.1111/j.1469-7580.2012.01537.x

Battiston KG, Labow RS, Santerre JP, Protein binding mediation of biomaterial-dependent monocyte activation on a degradable polar hydrophobic ionic polyurethane,  Biomaterials, 33, 8316-8328 (2012). https://doi.org/10.1016/j.biomaterials.2012.08.014

Blit, PH, Battiston KG, Yang M, Santerre JP, Woodhouse KA, Electrospun elastin-like polypeptide enriched polyurethanes and their interactions with vascular smooth muscle cells, Acta Biomaterialia, 8, 2493-2503 (2012). https://doi.org/10.1016/j.actbio.2012.03.032

McBane JE, Sharifpoor S, Labow RS, Ruel M,  Suuronen EJ, and Santerre JP,  Tissue Engineering a Small Diameter Vessel Substitute: Engineering Constructs Based on Non-traditional Biomaterials and Cell Sources, Current Vascular Pharmacology 10, 347-60 (2012). https://doi.org/10.2174/157016112799959378

McBane JE, Kuihua C, Labow RS,  and Santerre JP, Co-culturing monocytes with smooth muscle cells improves cell distribution within a degradable polyurethane scaffold and reduces inflammatory cytokines, Acta Biomaterialia, 8, 488-501 (2012). https://doi.org/10.1016/j.actbio.2011.09.018

Battiston KG, McBane JE, Labow RS, Santerre JP, Differences in protein binding and cytokine release from monocytes on commercial sources of tissue culture polystyrene,  Acta Biomaterialia, 8, 89-98 (2012). https://doi.org/10.1016/j.actbio.2011.09.015

McDonald S, Matheson LA, McBane JE, Kuraitis D,  Suuronen EJ, Santerre JP, Labow RS, Use of monocyte/endothelial cell co-cultures (in vitro) and a subcutaneous implant mouse model (in vivo) to evaluate a degradable, polar, hydrophobic, ionic polyurethane.  J Cell Biochem. 112, 3762-2772 (2011). https://doi.org/10.1002/jcb.23307

Blit P.H., McClung WG., Brash J.L., Woodhouse K.A., Santerre J.P. Platelet inhibition and endothelial cell adhesion on elastin-like polypeptide surface modified materials. Biomaterials, 32, 5790-5800 (2011). https://doi.org/10.1016/j.biomaterials.2011.04.067

McBane JE, Sharifpoor S, Kuihua C, Labow RS,  and Santerre JP, Biodegradation and in vivo biocompatibility of a degradable polar/hydrophobic/ionic polyurethane for  tissue engineering applications, Biomaterials. 32, 6034-44 (2011). https://doi.org/10.1016/j.biomaterials.2011.04.048

Sharifpoor S, Simmons CA, Labow RS, Santerre JP, Functional characterization of human coronary artery smooth muscle cells under cyclic mechanical strain in a degradable polyurethane scaffold, Biomaterials, 32, 4816-29 (2011). https://doi.org/10.1016/j.biomaterials.2011.03.034

McBane JE, Battiston KG, Wadhwani A, Sharifpoor S, Labow RS, Santerre JP, The effect of degradable polymer surfaces on co-cultures of monocytes and smooth muscle cells, Biomaterials, 32, 3584-95, (2011). https://doi.org/10.1016/j.biomaterials.2011.01.069

Blit, PH, Battiston KG, Woodhouse KA, Santerre JP, Surface emobilization of elastin-like polypeptides using fluorinated surface modifying additives, J Biomed Mater Res, 96A, 648-662 (2011). https://doi.org/10.1002/jbm.a.33022

Attia M, Santerre JP, Kandel RA, The response of annulus fibrosus cell to fibronectin-coated nanofibrous polyurethane-anionic dihydroxyoligomer scaffolds, Biomaterials, 32, 450-460 (2011). https://doi.org/10.1016/j.biomaterials.2010.09.010

Srokowski E.M., Blit P.H., McClung G.W., Brash J.L, Santerre J.P., Woodhouse K.A., Platelet Adhesion and Fibrinogen Accretion on a Family of Elastin-Like Polypeptides, J Biomat Sci-Polym Ed, 22 (1-3), 41-57 (2011). https://doi.org/10.1163/092050609X12578498935594

McBane JE, Diba Ebadi , Soroor Sharifpoor, Rosalind S. Labow, J. Paul Santerre, Differentiation of monocytes on a degradable, polar-hydrophobic-ionic polyurethane: 2-dimensional films versus 3-dimensional scaffolds, Acta Biomaterialia, 7: 115–122 (2011). https://doi.org/10.1016/j.actbio.2010.08.014

Sharifpoor S, Simmons CA, Labow RS, Santerre JP, A study of vascular smooth muscle cell function under cyclic mechanical loading in a polyurethane scaffold with optimized porosity, Acta Biomaterialia,  6: 4218-4228 (2010). https://doi.org/10.1016/j.actbio.2010.06.018

Kermanshahi S, Santerre JP, Cvitkovitch D, Finer Y, Biodegradation of Resin-Dentin Interfaces Increases Bacterial Microleakage,  J Dent Res, 89(9):996-1001, 2010. https://doi.org/10.1177%2F0022034510372885

Yeganegi M, Kandel RA, Santerre JP, Characterization of a biodegradable electrospun polyurethane nanofiber scaffold: Mechanical properties and cytotoxicity, Acta Biomaterialia, 6: 3847-3855 (2010). https://doi.org/10.1016/j.actbio.2010.05.003

Blit P, Shen YH, Ernsting MJ, Woodhouse KA, Santerre JP, Bioactivation of porous polyurethane scaffolds using fluorinated RGD surface modifiers, J Biomed Mater Res, 94(4):1226-35 (2010). https://doi.org/10.1002/jbm.a.32804

Shokati B, Tam LE, Santerre JP, Finer Y, Effect of Salivary Esterases on the Integrity and Fracture Toughness of the Dentin-Resin Interface, J Biomed Mater Res: Appl Biomater 94B:230-237 (2010). https://doi.org/10.1002/jbm.b.31645

Ramsay SD, Pilliar RM, Santerre JP, Fabrication of a biodegradable calcium polyphosphate/polyvinyl‐urethane carbonate composite for high load bearing osteosynthesis applications, J Biomed Mater Res part B, 94B, 178-186 (2010). https://doi.org/10.1002/jbm.b.31639

Sharifpoor S, Labow RS, Santerre JP, The synthesis and characterization of degradable polar hydrophobic ionic polyurethane porous scaffolds for vascular tissue engineering applications, Biomacromolecules, 10 (10): 2729–2739 (2009). DOI:10.1021/bm9004194

McBane JE, Matheson LA,  Sharifpoor S,  Santerre JP, Labow RS, Effect of polyurethane chemistry and protein coating on monocyte differentiation to a wound healing phenotype macrophage, Biomaterials, 30, 5497-5504 (2009). https://doi.org/10.1016/j.biomaterials.2009.07.010

Yang L, Kandel R, Santerre JP, Polar Surface Chemistry of Nanofibrous Polyurethane Scaffold Affects Annulus Fibrosus Cell Attachment and Early Matrix Accumulation, J Biomed Mater Res, 91(4):1089-99 (2009). https://doi.org/10.1002/jbm.a.32331

McBane JE, Matheson LA, Santerre JP, Labow RS , The effects of phorbol ester activation and reactive oxygen species scavengers on the macrophage-mediated foreign body reacton to polyurethanes, J Biomed Mater Res, 91A: 1150–1159 (2009). https://doi.org/10.1002/jbm.a.32261

Khalichi P, Singh J, Cvitkovitch D, Santerre JP, The influence of triethylene glycol derived from dental on the regulation of Streptococcus mutans gene expression, Biomaterials, 30:452-459 (2009). https://doi.org/10.1016/j.biomaterials.2008.09.053

Singh J, Khalichi P, Cvitkiovitch DG, Santerre JP, Composite resin degradation products from BisGMA monomer modulate the expression of genes associated with biofilm formation and other virulence factors in Streptococcus mutans, J Biomed Mater Res, 88A:551–560, (2009). https://doi.org/10.1002/jbm.a.31879

McBane JE, Matheson LA, Santerre JP, Labow RS, Effect of phorbol esters on the macrophage-mediated biodegradation of polyurethanes via protein kinase C activation and other pathways, J of Biomaterials Sci, Poym Ed, 20, 437-453 (2009). https://doi.org/10.1163/156856209X416467

Dinnes DLM, Santerre JP, Labow RS, Intracellular phospholipase A(2) expression and location in human macrophages: Influence of synthetic material surface chemistry, J Cellular Physiology;214(1):136-44 (2008). https://doi.org/10.1002/jcp.21171

Dinnes DLM, Santerre JP, Labow RS, Influence of biodegradable and non-biodegradable material surfaces on differentiating human monocyte-derived macrophages, Differentiation, 76, 232-244 (2008). https://doi.org/10.1111/j.1432-0436.2007.00221.x

McBane JE, Santerre JP, Labow RS, The interaction between hydrolytic and oxidative pathways in macrophage-mediated polyurethane degradation, J Biomed Mater Res, 82A(4), 984-94 (2007). https://doi.org/10.1002/jbm.a.31263

Ernsting M, Labow RS, Santerre JP, Human monocyte adhesion onto RGD and PHSRN peptides delivered to the surface of a polycarbonate polyurethane using bioactive fluorinated surface modifiers, J. Biomed Mater Res, 83A, 759-769 (2007). https://doi.org/10.1002/jbm.a.31370

Matheson LA, Maksym GN, Santerre JP, Labow RS, Differential effects of uniaxial and biaxial strain on U937 macrophage-like cell morphology: Influence of extracellular matrix type proteins, J Biomed Mater Res, 81A:971-891 (2007). https://doi.org/10.1002/jbm.a.31117

Matheson LA, McBane JE, Malowany JI, Santerre JP, Labow RS, Is cell culture stressful? A comparison of the effects of degradable and non-degradable culture surfaces on U937 cell function and morphology, BioTechniques, 42, 744-450 (2007). https://doi.org/10.2144/000112460

Gratzer, P.F., Santerre, J.P., Lee J.M., The effect of chemical modification of amino-acid side chains on collagen degradation by enzymes, J Biomed Mater Res.: Part B, Applied Biomaterials, 81B, 1-11(2007). https://doi.org/10.1002/jbm.b.30629

Finer Y, Santerre JP, The influence of silanated filler content on the biodegradation of bisGMA/TEGDMA dental composite resins, J Biomed Mat Res, 81A, 75-84(2007). https://doi.org/10.1002/jbm.a.31004

Merdad K, Pascon EA, Kulkarni G, Santerre P, Friedman S, Short-term cytotoxicity assessment of components of the epiphany resin-percha obturating system by indirect and direct contact millipore filter assays, J Endodontics, 33, 24-27(2007). https://doi.org/10.1016/j.joen.2006.10.003

Massa T, McClung G, Yang M, Ho JYC, Brash JL, Santerre JP, Fibrinogen adsorption and platelet lysis characterization of fluorinated surface modified polyetherurethanes, J Biomed Mater Res, 81A, 178-185(2007). https://doi.org/10.1002/jbm.a.30936

Dinnes DL, Marcal H, Mahler SM, Santerre JP, Labow RS, Material surfaces affect the protein expression patterns of human macrophages: a proteomic approach, J Biomed Mater Res, 80, 895-908 (2007). https://doi.org/10.1002/jbm.a.30967

Labow RS, Santerre JP, Effect of fibrinogen adsorption on U937-cell mediated biodegradation of polycarbonate-polyurethanes, in New Research on Biomaterials, Ed. Denzel R. Boomington, Nova Science Publishers, Inc, Hauppauge, NY, USA., Chapter 5 p145-159, 2007.