New Biomaterials for Tissue Engineering

Polyurethanes have become a popular material in biomedical engineering due to their versatile segmented block co-polymeric structure and associated flexible biocompatibility and biodegradation characteristics. The Santerre laboratory has thoroughly investigated biodegradation mechanisms of synthetic polyurethanes and focused on developing new polyurethane biomaterials that modulate immune cell (e.g. monocyte/macrophage) activation to support favourable cell-material/cell-cell interactions for new tissue regeneration. One example of the novel polyurethanes developed by the Santerre laboratory is a degradable polar hydrophobic ionic (D-PHI) polyurethane. D-PHI has been shown to have good biocompatibility, controlled biodegradation rate and tunable mechanical properties. Furthermore, D-PHI has been demonstrated to stimulate low-inflammatory phenotype of immune cells and promote functional marker expression of both vascular smooth muscle cells and endothelial cells, suggesting its great potential in engineering mature vascular tissues as well as other soft tissue engineering applications.

Relevant Publications:

Battiston, Kyle G., Rosalind S. Labow, and J. Paul Santerre. 2012. “Protein Binding Mediation of Biomaterial-Dependent Monocyte Activation on a Degradable Polar Hydrophobic Ionic Polyurethane.” Biomaterials 33(33):8316–28.

Cheung, Jane W. C., Devika Jain, Christopher a G. McCulloch, and J. Paul Santerre. 2015. “Pro-Angiogenic Character of Endothelial Cells and Gingival Fibroblasts Cocultures in Perfused Degradable Polyurethane Scaffolds.” Tissue engineering. Part A 21:1–13.

McBane, Joanne E., Loren a Matheson, Soroor Sharifpoor, J. Paul Santerre, and Rosalind S. Labow. 2009. “Effect of Polyurethane Chemistry and Protein Coating on Monocyte Differentiation towards a Wound Healing Phenotype Macrophage.” Biomaterials 30(29):5497–5504.

McBane, Joanne E., Soroor Sharifpoor, Kuihua Cai, Rosalind S. Labow, and J. Paul Santerre. 2011. “Biodegradation and in Vivo Biocompatibility of a Degradable, Polar/hydrophobic/ionic Polyurethane for Tissue Engineering Applications.” Biomaterials 32(26):6034–44.