Protein and Blood Interactions
One of the first events that occurs following the implantation of biomaterials is adsorption of proteins from protein-rich bodily fluids (e.g. blood, interstitial fluid) that translates the biomaterial surface into a new biological substrate that will guide subsequent cellular and tissue interactions. Protein adsorption plays an important role in regulating blood biocompatibility, immune cell activation, stem cell differentiation, and other cellular activities. The Santerre laboratory is interested in the study of protein-biomaterial interactions, particularly in the context of blood biocompatibility and immune cell activation. Understanding how biomaterial properties (e.g. surface chemistry, roughness, surface energy) regulate protein interactions in a manner that can reduce pro-inflammatory immune cell activation or minimize platelet adhesion allows for intelligent design of new biomaterials with properties desirable for different applications.
Battiston KG, Labow RS, Santerre JP. Protein binding mediation of biomaterial-dependent monocyte activation on a degradable polar hydrophobic ionic polyurethane. Biomaterias 2012;33(33):8316-28.
Blit PH, McClung WG, Brash JL, Woodhouse KA, Santerre JP. Platelet inhibition and endothelial cell adhesion on elastin-like polypeptide surface modified materials. Biomaterials 2011;32(25):5790-800.
Massa TM, Yang ML, Ho JY, Brash JL, Santerre JP. Fibrinogen surface distribution correlates to platelet adhesion pattern on fluorinated surface-modified polyetherurethane. Biomaterials 2005;26(35):7367-76.
Jahangir R, McCloskey C, McClung WG, Labow RS, Santerre JP. The influence of protein adsorption and surface modifying macromolecules on the hydrolytic degradation of a poly(ether-urethane) by cholesterol esterase. Biomaterials 2003;24(1):121-30.